Hereditary ATTR amyloidosis
Tafamidis Meglumine (Vyndaqel®) Treats Cardiomyopathy
Both Vyndaqel and Vyndamax contain the same active ingredient called tafamidis. The difference between Vyndaqel and Vyndamax lies in the form of tafamidis they contain. Vyndaqel contains the micronized meglumine salt of tafamidis, while Vyndamax contains the free acid form of tafamidis
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Inotersen (Tegsedi®) – Treats polyneuropathy
TEGSEDI is the first and only self-administered injection for the polyneuropathy of hATTR amyloidosis in adults. Regular lab monitoring of platelet count and renal liver function is required during treatment with TEGSEDI.
Inotersen (Tegsedi®) – Treats polyneuropathy Read More »
Fatigue (Cardiac Amyloidosis / General Organ Stress)
When amyloid proteins overwhelm your organs, you may not have the energy and strength you once had. Amyloidosis can cause severe, unusual fatigue. You may not feel up to doing the activities you once enjoyed. You may even need frequent naps during the day. [source: healthline]
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Patisiran (Onpattro®) – Treats polyneuropathy
Patisiran is the first-ever RNA interference drug consisting of short, double-stranded interfering ribonucleic acid (siRNA) encapsulated in a lipid nanoparticle and targeted to inhibit hepatic synthesis of transthyretin, both the wild-type and mutant. [source: Pubmed]
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Carpal Tunnel Syndrome (Amyloid Neuropathy)
In patients undergoing surgery for idiopathic CTS, a recent study identified amyloidosis by tenosynovial biopsy in 10.2% of men older than 50 years and women older than 60 years; all positive patients had bilateral symptoms. [source: NIH]
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