Purple lesions on the skin (Purpura)
The precise cause of amyloid purpura is unknown, but several mechanisms are thought to contribute. One may be a decrease in the level of circulating factor X, a clotting factor necessary for coagulation.
AL (Primary)
Bone Marrow / Stem Cell Transplant
Stem cell transplantation (SCT) is an effective treatment for amyloidosis , but it’s not a cure. Amyloidosis will return in everyone. However, some patients have been successfully treated with SCT and have been able to receive another SCT when their disease progressed.
Spleen
While amyloidosis may be systemic or localized, splenic involvement is fairly common (5–10%) and generally asymptomatic [3]. When splenic rupture secondary to localized amyloidosis occurs, it is usually the first manifestation of the disease process. This case illustrates spontaneous splenic rupture due to localized amyloidosis as an important consideration in the differential of acute abdominal …
Fatigue (Cardiac Amyloidosis / General Organ Stress)
When amyloid proteins overwhelm your organs, you may not have the energy and strength you once had. Amyloidosis can cause severe, unusual fatigue. You may not feel up to doing the activities you once enjoyed. You may even need frequent naps during the day. [source: healthline]
Primary nonfamilial ocular amyloidosis
Ocular amyloidosis is a rare cause of vitreous haze1,2 and should be included in the differential diagnosis of vitreous opacification. The ophthalmologist should be aware that ocular amyloidosis may occur sporadically and that vitreous biopsy with specific staining with Congo red dye may be indicated.
Carpal Tunnel Syndrome (Amyloid Neuropathy)
In patients undergoing surgery for idiopathic CTS, a recent study identified amyloidosis by tenosynovial biopsy in 10.2% of men older than 50 years and women older than 60 years; all positive patients had bilateral symptoms. [source: NIH]