Spleen

While amyloidosis may be systemic or localized, splenic involvement is fairly common (5–10%) and generally asymptomatic []. When splenic rupture secondary to localized amyloidosis occurs, it is usually the first manifestation of the disease process. This case illustrates spontaneous splenic rupture due to localized amyloidosis as an important consideration in the differential of acute abdominal pain. It also highlights amyloidosis as a potential marker for other systemic disease that may only be recognized or investigated after splenic pathology is elucidated.